Technical Guides

Choosing a biological buffer: HEPES, Tris, MES, MOPS and PIPES compared – KUGAKI technical guide cover19 Oct 2026 Choosing a biological buffer: HEPES, Tris, MES, MOPS and PIPES compared Match the buffer to your working pH, temperature and assay. A practical comparison of HEPES, Tris, MES, MOPS and PIPES, with the pitfalls that cause drifting pH and failed assays.